Prequel bonuses - Enter the store, and press Square to detect a saved game file from Uncharted: Drake's Fortune. You will get $20,000 for having a saved game file, and an additional $80,000 for having a completed saved game file. The money can be used in the single player and multiplayer stores.

Bonus skins - Successfully complete the indicated task to unlock the corresponding skin for purchase:

Cameraman Jeff: Reach Level 30 ($100,000).
Doughnut Drake: Reach Level 60 ($2,000,000).
Genghis Khan Villain: Successfully complete the game on the Crushing difficulty ($1.5 million).
Harry Flynn: Reach Level 20 ($50,000).
Heist Drake: Reach Level 10 ($20,000).
Heist Flynn: Reach Level 20 ($50,000).
Karl Schafer: Reach Level 50 ($1,000,000).
Lieutenant Draza: Reach Level 50 ($1,000,000).
Marco Polo Hero: Unlock the Platinum trophy ($0).
Skelzor: Reach Level 60 ($2,000,000).
Winter Chloe: Reach Level 20 ($50,000).
Winter Drake: Reach Level 40 ($250,000).
Winter Elena: Reach Level 30 ($100,000).
Winter Flynn: Reach Level 30 ($100,000).
Zoran Lazarevic: Reach Level 40 ($250,000).
Zorskel: Reach Level 10 ($20,000).

Multiplayer boosters - Reach the indicated level to unlock the corresponding booster for purchase in Multiplayer mode:

Bandoleer (Booster Slot 2): Level 4 ($2,000)
Break Up (Booster Slot 1): Level 10 ($11,250)
Come Get Some (Booster Slot 2): Level 58 ($2,000,000)
Deposit (Booster Slot 2): Level 40 ($98,250)
Down the Irons (Booster Slot 1): Level 14 ($18,750)
Evasion (Booster Slot 1): Level 50 ($210,000)
Explosive Expert (Booster Slot 2): Level 20 ($32,250)
Fleet Foot (Booster Slot 2): Level 16 ($23,250)
From the Hip (Booster Slot 1): Level 6 ($5,000)
Glass Jaw (Booster Slot 1): Level 56 ($1,500,000)
Half Loaded (Booster Slot 2): Level 54 ($400,000)
Hell Blazer (Booster Slot 1): Level 18 ($27,750)
Invalid (Booster Slot 1): Level 52 ($350,000)
Juggler (Booster Slot 1): Level 38 ($94,500)
Keep Firing (Booster Slot 2): Level 12 ($14,250)
Launch Man (Booster Slot 2): Level 28 ($58,500)
Monkey Man (Booster Slot 2): Level 32 ($72,000)
Point and Shoot (Booster Slot 1): Level 2 ($2,000)
Rapid Hands (Booster Slot 1): Level 42 ($111,000)
Revenge (Booster Slot 2): Level 48 ($134,250)
Rocket Man (Booster Slot 2): Level 44 ($120,000)
Scavenger (Booster Slot 2): Level 8 ($8,250)
Scoped In (Booster Slot 2): Level 36 ($87,000)
Situational Awareness (Booster Slot 1): Level 46 ($129,000)
Sure Foot (Booster Slot 2): Level 26 ($52,500)
Sure Shot (Booster Slot 1): Level 30 ($64,500)
Treasure Bearer (Booster Slot 2): Level 24 ($43,500)
Turtle (Booster Slot 1): Level 22 ($40,500)
Veiled (Booster Slot 1): Level 51 ($300,000)
Walk Softly (Booster Slot 1): Level 34 ($79,500)

Multiplayer taunts - Reach the indicated level to unlock the corresponding taunt for purchase in Multiplayer mode:

Flex: Level 20 ($50,000)
Flurry: Level 30 ($100,000)
Kiss: Level 10 ($10,000)
Pump: Level 53 ($500,000)
Yes: Level 40 ($250,000)

Crushing mode - Successfully complete the game on the Hard difficulty to unlock the Crushing difficulty.

Easy money - Successfully complete a task that rewards you with a lot of money. Save the game if it is not at an auto-save area. Exit out to the main menu. Then, load the game to get the reward again. Repeat this as many times as desired.

In Chapter 6, find the pool on a hotel roof. Jump in the pool and swim around to have Chloe and Nate play a game of Marco Polo and get $10,000.

Flynn's reaction - In Chapter 24 when Flynn forces you to find a way to turn the bridge, press Square to turn and swing at him. He will dodge your attack, knock you down, and give you a message. If you do it again, he will shoot and kill you.

Hidden Sully pictures - When you are prompted to view your journal by pressing Select, keep flipping back to find an entry with four pictures of Sully, which Nate has apparently drawn over and labeled according to his expression.

Defeating Guardians - To easily kill the Guardians you fight later in the game, once you kill one, take the gold crossbow it drops, and use it on the others to kill them much quicker than your normal guns.

Defeating Lazarevic - To defeat Lazarevic, you must lure him near the volatile blue sap throughout the level. When he is within range, shoot the sap to cause it to explode.

Uncharted: Drakes Fortune references - When you are prompted to view your journal by pressing Select, look for the picture labeled "Angry Eddy". Eddy was one of Drake's enemies from Uncharted: Drakes Fortune. Additionally, one of the unlockable guns in Single Player mode is a gun used by Angry Eddy.

Trophies - Successfully complete one of the following tasks to get a trophy:

First Treasure (Bronze): Find one treasure.
Apprentice Fortune Hunter (Bronze): Find ten treasures.
Novice Fortune Hunter (Bronze): Find 20 Treasures.
Cadet Fortune Hunter (Bronze): Find 30 treasures.
Intermediate Fortune Hunter (Bronze): Find 40 treasures.
Practiced Fortune Hunter (Bronze): Find 50 treasures.
Proficient Fortune Hunter (Bronze): Find 60 treasures.
Professional Fortune Hunter (Bronze): Find 70 treasures.
Expert Fortune Hunter (Bronze): Find 80 treasures.
Crack Fortune Hunter (Bronze): Find 90 treasures.
Relic Finder (Bronze): Find the Strange Relic.
20 Headshots (Bronze): Defeat 20 enemies with headshots.
100 Headshots (Bronze): Defeat 100 enemies with headshots.
Headshot Expert (Bronze): Defeat five enemies in a row with headshots.
Run-and-Gunner (Bronze): Defeat 20 enemies by shooting from the hip (without aiming with L1).
Hangman (Bronze): Defeat 20 enemies with gunfire by aiming while hanging.
50 Kills: 92FS - 9mm (Bronze): Defeat 50 enemies with the 92FS - 9mm.
50 Kills: Micro - 9mm (Bronze): Defeat 50 enemies with the Micro - 9mm.
30 Kills: Wes - 44 (Bronze): Defeat 30 enemies with the Wes - 44.
30 Kills: Desert - 5 (Bronze): Defeat 30 enemies with the Desert - 5.
20 Kills: Pistole (Bronze): Defeat 20 enemies with the Pistole.
70 Kills: FAL (Bronze): Defeat 70 enemies with the FAL.
70 Kills: M4 (Bronze): Defeat 70 enemies with the M4.
50 Kills: Dragon Sniper (Bronze): Defeat 50 enemies with the Dragon Sniper.
30 Kills: Moss - 12 (Bronze): Defeat 30 enemies with the Moss - 12.
70 Kills: SAS - 12 (Bronze): Defeat 70 enemies with the SAS - 12.
50 Kills: M32 - Hammer (Bronze): Defeat 50 enemies with the M32.
30 Kills: RPG - 7 (Bronze): Defeat 30 enemies with the RPG - 7.
200 Kills: GAU - 19 (Bronze): Defeat 200 enemies with the GAU - 19.
30 Kills: Mk-NDI (Bronze): Defeat 30 enemies with the Mk-NDI.
Triple Dyno-Might (Bronze): Defeat three enemies with one explosion.
Grenade Hangman (Bronze): Defeat ten enemies with grenades by aiming while hanging.
Bare-knuckle Brawler (Bronze): Defeat 20 enemies with hand-to-hand combat.
Steel Fist Master (Bronze): Defeat 20 enemies with a single punch, after softening them up with gunfire.
Thrillseeker (Bronze): Complete one Competitive Multiplayer game.
Buddy System (Bronze): Complete one Cooperative Multiplayer game.
Master Fortune Hunter (Silver): Find all 100 treasures.
Survivor (Silver): Defeat 75 enemies in a row without dying.
250 Headshots (Silver): Defeat 250 enemies with headshots.
Bare-knuckle Slugger (Silver): Defeat 50 enemies with hand-to-hand combat.
Bare-knuckle Expert (Silver): Defeat ten enemies in a row with hand-to-hand combat.
Master Ninja (Silver): Defeat 50 enemies with stealth attacks.
Steel Fist Expert (Silver): Defeat ten enemies in a row with a single punch, after softening them up with gunfire.
Charted - Easy (Silver): Finish the game in Easy Mode.
Charted - Normal (Gold): Finish the game in Normal Mode.
Charted - Hard (Gold): Finish the game in Hard Mode.
Charted - Crushing (Gold): Finish the game in Crushing Mode.
Platinum (Platinum): Unlock all trophies.