Additional slots:-  When you first get to the trolley, Carlos will give you a "fanny" pack. After you finish the game, you will keep those additional two slots in the game.

Starting the trolley:-  The oil additive needed to start the trolley is located in a locked store room inside the sales office. To unlock it, pick up the flashy remote on a desk to turn on a TV. You will see a commercial about some product from Ubrella Corp. Make note of that product (Safsprin, Adravil, Aquacure, etc.). Go to the nearby computer where Carlos just shot his zombied friend. You  will be prompted for a password. Type in the name of the product to unlocked the storeroom.

Fighting Nemesis:-  The Nemesis is left-handed and uses that hand to grab you. When fighting him, shoot him two times and run past his right side. Shoot twice and repeat the process. Note: This only works when he does not have his Rocket Launcher and if you are using the handgun. 

Nemesis Type 2 in mercenary mode and 220 second bonus:-  Get to the parking garage, then exit out of the door. If you still have over two minutes left, run to the end of the bus and you will see Nemisis Type 2. He will jump down and come after you. You can run around him to avoid his attacks and save ammo or you can kill him for 220 seconds. Note: This trick best works with Mikhail

Kill regular Nemesis for 60 seconds of bonus time:-  Knocking him down the first time is worth a 20 second bonus. Knocking him down a second time will cause him to look dead with a pool of blood around him and is worth a 40 second bonus.

Destroy Nemesis' Rocket Launcher:-  This trick requires a large number of health items and first aid sprays. When you fight the Nemesis with the Rocket Launcher, aim up. If he targets you, run and try to make him waste ammunition. After four to seven shots from him, he will reload, but the rocket launcher will turn red and explode.

When you hear the reload sound he makes with his launcher and he aims at you, shoot him when he is about to shoot you. Almost always, the launcher will backfire and explode.

Loose parts from Nemesis:-  Whenever you kill Nemesis in Hard Mode, you can always pick up a package that he drops, containing gun parts. Once these are assembled, they form the Eagle 6.0 STI. This gun is more convenient than the standard handgun. Once you get close to a zombie, aim directly at its head and fire. If performed correctly, you will shoot its head off just like what a magnum regularly would, and it only consumes regular handgun bullets.

Fighting a Doggie:-  Knock down a Doggie, then aim down and you can fire faster on it. If you do not aim down, you have to wait until the Doggie stands up.

Humanoid sighting:-  When fighting the Nemesis for the last time in the Rail Gun Room, you will see a figure in the background, similar to Nemesis. Closely observe the creature to see that it is the Humanoid, or the Mutated William Burken from Resident Evil 2.  When you press Action, Jill describes it as "One of Umbrella's New Biotech Weapons".

Alternate meeting with Carlos:-  You can meet Carlos at the top floor of the newspaper building instead of the restaurant when you first come out of the area after you fought the first Licker. You will hear Carlos taking out a few zombies. Ignore that and go to Jill's left. Enter the door at that location. You will now be at the alley directly behind the restaurant. From here, make your way to  the newspaper office. After meeting Carlos, Nemesis appears. You will get to make a choice to "Jump out the window", or "Hide in the back". Note: To get the green gem, go back to the restaurant and go down the ladder. Then, check the police officer down there. He should have it.

The Worm:-  You actually do not have to fight the Worm the first time you meet him, when you fall into the sewer. After he pops out of the wall the first time, just run to your right and hit the first switch (make sure the worm comes out of the wall). Then,  run to the other side of the sewer and hit the second switch (this one may be difficult -- also make sure the worm comes out again). Then, press the button for the ladder and you just saved yourself some life and ammunition.

Defeating the Worm:-  Use the following trick to defeat the Worm without wasting good ammunition. Walk slightly into the Worm's little section slowly until the screen starts to shake and he appears. Back up to the wall and shoot him with the handgun. If the worm does reach you, which is not very often, Jill will usually dodge to the right. Repeat until it is defeated. To defeat the second Worm, run around for two minutes and try not to take damage. After that time, the light pole will begin to spark. Use the handgun to shoot in the direction of the two sparking poles and they will fall into a puddle. Stand near (not in) the puddle, then wait for the worm to go into the water and fry to death.

Grenade Launcher or Magnum:-  Your timing will determine whether the Grenade Launcher or the Magnum can be found at the S.T.A.R.S. Office. If you go to the cabinet before the radio goes off, when you try to leave you will get the Grenade Launcher. If you go to the cabinet after the radio goes off you will get the Magnum. Whichever weapon is obtained, the other will be found in the power plant.

Grenade launcher:-  Use the S.T.A.R.S Card in the computer in the main entrance of the Police Station. When you get the S.T.A.R.S Emblem Key, go to the S.T.A.R.S Office. When you are in the office, go to the big locker next to the out-of-commission message receiver. Open the locker and you will get a Grenade Launcher.

There are two different ways to get the Grenade launcher. There is one in the Sub-Station when the game is first played. The other is available after the game has been completed once. Go to the S.T.A.R.S. office and go were the Magnum gun was originally obtained. 

Rocket launcher:-  In the dead factory, go to the machine next to the water sample puzzle. Use the facility key where that game states a small plastic card can be inserted. Take the other facility key that is given and go to the steaming room where the small  card activated elevator is located .Go down and use the facility key on the door where that game states a small plastic card can be inserted. You will find a rocket launcher with four shots at this location.

STI Eagle handgun:-  Kill Nemesis two times under the hard difficulty setting to get the two parts for it. Combine them to get the STI Eagle handgun.

Assault rifle with unlimited ammo (hard mode):-  Kill Nemesis seven times in your first game and he will drop the assault rifle. Kill him seven times in your second game he will drop an infinite ammo case.

Conserve assault rifle ammunition: -  Set the mode to "Manual". Every time you shoot, only three rounds will be used and the total percentage of ammo left will decrease by about 1%. Use the assault rifle like this until you can fire it without wasting large amounts of ammunition when it is set to "Auto".

Killing multiple zombies with shotgun:-  You can easily blast off the heads of multiple zombies with a shotgun. Get some zombies close together. Aim the shotgun up. Get close to the zombies (but not too close). While the shotgun is aimed up, and you are close, fire. Note: This works well for Mikhail in the mercenaries mode. 

Get vaccine:-  When playing as Carlos in the Hospital 4F, go to the unlocked Sickroom and look at the corner where the movable cabinet is located. Remember where it is. Read the note on the dead doctor's hands in that room. Use the Sickroom Key on the next  room over. In that room, push the cabinet in the opposite corner of where the cabinet in the previous room was found. For example, if the first cabinet is in the upper left corner of the first sickroom, than push the second cabinet into upper right corner of the second sickroom. A painting in the room will slide, revealing a machine holding the vaccine base. Enter the numbers that were on the dead doctor's note in order to obtain the vaccine base. 

Vaccine medium combination:-  One of the combinations when making the vaccine medium in the hospital is I, III, and A.

Mine Thrower with tracking, enhanced shots:-  Either get $9999 in Mercenary mode and buy unlimited ammunition or use the infinite ammo kit obtained from Nemesis on the Mine Thrower. The Mine Thrower will have tracking bullets which will show the directions to the zombies.

Unlimited money and time in mercenaries mode:-  Get to the alley that has three dogs and a crate. Kill two of the dogs get on the crate. Continuously dodge the remaining dog for a time and money bonus for dodging.

Civilian locations in mercenaries mode:-  The civilians that must be saved in mercenaries mode may be found at the following locations. Note: You must save them in this order or some of them will die. Also, You must kill all the enemies in the room with the civilians or they will not be saved.

1. Gas Station
2. Basement of the Restaurant
3. Third Floor of the Raccoon Press Office
4. Sub Station (where you got the fuse)
5. Sales Office
6. The Bar 

Mercenary mode item box:-  Once you complete mercenary mode with each character and bought all the weapons you can access the item box, but it only contains a knife.

S rank in mercenary mode:-  Get the combat knife, kill many monsters, rescue all civilians, and do not use healing items. Then kill every monster with the knife. You should end up with over an hour and some change. 

330 seconds in mercenary mode:-  Go to the part of the mercenary mission with two Nemeses and take out your knife. The Nemeses will kill each other, and you will earn 330 seconds.

Larger reward in mercenary mode:-  Try to reach the area near the goal (just after the dimly lit hallway, near the intersection) with more than four minutes remaining on the game clock. Two more of the STARS-killing Nemeses will appear, both armed with makeshift rocket launchers!. This achievement results in a larger reward from the Big Fat Boss. 

Identity of the rewarder in mercenary mode:-  The identity of the fat man who hands out the reward money in mercenary mode is Brian Irons, the police chief. To confirm this, look at his shirt.

Get the S.T.A.R.S. card faster:-  This trick allows you to get the S.T.A.R.S. card faster without having to go further into the police station and wasting ammo for Jill's card for the computer to get the password to the drawer where the S.T.A.R.S. Room Key is  located. After Brad is dead near the entrance of the police station, you have choose between fighting the monster or entering the police station. Choose to fight the monster. When you do this, remember that Nemesis is left handed. When he comes at you, run past his right side and you will not get hurt. You should get near Brad's body so you can check it. If completed; you can grab his card case and dodge Nemesis to enter the doors of the police station. When inside, go into the items menu and check on the card case to get his S.T.A.R.S. card. You can use it on computer for the password for the S.T.A.R.S. Room Key.

Killing Zombies quicker under the hard difficulty setting:-  If you are using shotgun rounds, wait until the zombie is directly in front of you, then aim up to fire. This will blow their head off, killing them immediately and save one round of shotgun ammo per zombie. If you are using handgun rounds, carry your knife, and only shoot them until they fall. Then, finish them off with the knife.

Getting Mikhail to kill Zombies with the oil drum:-  Get everything except the oil, then go to the trolley. If you destroyed the oil drum, Mikhail will throw a grenade killing the zombies. But if you did not destroy the oil drum, Mikhail will kick it towards the Zombies and shoot it with his gun, killing them. 

Checking zombies:-  To tell if zombies are still active after they are hit, leave the room. If the zombie is still on the floor, he is still  active. 

Walk back and forth in front of their head or enable the auto aim feature and press Aim.

If you are not sure if a zombie or a dead body is present, look for a shadow. If there is a shadow under the corpse, it is still alive. When you see no shadow or when it lies in a pile of blood, it is dead.

If you are not sure if a zombie is dead, walk up fairly close to it (but not so close that they start chewing your ankles) and simply back up. If the Zombie is alive, the character will do a wary backup move instead of the standard backup done when there is nothing there.

Run on one foot:-  When running, quickly and repeatedly tap Square. Jill will run on one foot, and her other foot will never touch the ground.

Spinning Jill:-  Note: A controller with an auto-fire feature is required for this trick. Turn on the auto-fire, then have Jill walk  backwards and press the bvutton to have her turn around. If done correctly, she will spin around on one foot.

Campaign sign:-  Go to the end of the hall with the save room behind the restaurant to find political campaign signs. Look closely to 
will see a sign that says "OTOM for U...S Senat". 

Locker combination:-  When entering the Police Station and going into the door in the top left corner, you will reach a room with zombies. After killing them, enter the next room, which contains the lockers. Go to the other side to find a locker with a light on it. The game will prompt for a code. The code (varies by game) is either "0131", "0513", "4011", or "4312". 

Park fountain solution:-  When using the water control unit in Raccoon Park to drain the fountain, you have to align the gray and black gears. The gears need to be moved in the following order to correctly align them and drain the fountain. Move the bottom left black gear up. Move the top center gray gear down. Move the top right gray gear to the left. Move the bottom right black gear  up. Move the top center gray gear down. Move the top left black gear to the right. 

Water sample solution:-  When using the water sample machine in the abandoned Waste Processing Plant (Dead Factory), you have align the three lines of the water sample correctly to process the sample. There are four possible solutions (varies by game): A: 4 
Right, B: 2 Right, C: 2 Left. A: 1 Right, B: 1 Right, C: 2 
Left. A: 1 Left, B: 2 Left, C: 2 Right. A: 1 Right, B: 3 
Right, C: 4 Left. This will unlock half of the lock to the door next to the elevator. 

Sales passwords:-  In the sales, the passwords are either "ADRAVIL", "SAFSPRIN", or "AQUACURE". 

Oil truck from Resident Evil 2:-  When going to the trolley, look ahead as you climb the boxes. You can see the truck that crashed in Resident Evil 2 in the opening sequence.

Glitch: Two Nemesis with rocket launchers:-  Get to the alley behind the bar. Walk out into the alleyway until you see stairs. Nemesis will appear with a rocket launcher, but before he can shoot a second Nemesis will shoot at you but will hit the first Nemesis and knock him down.

Defeating Nemesis on the hard difficulty 

GameShark codes
Extracted Tofu mercenary mission:
Note: This trick requires a GameShark or Pro Action Replay 
cartridge. Enable the following code in the North American version of the game: 

800D3D3E 000F
800D3D54 000F 

Originally, Tofu was in mercenary mode. He was unlocked by completing mercenary mode with a S ranking with all the characters. However, he was taken out of the game. After enabling this code and when you rescue civilians, you will get the items he would have received. Also, when you complete his mission, the game will say that you were Tofu.

Play as Tofu:-  Note: This trick requires a GameShark or Pro Action Replay cartridge. Enable the following code in the North American version of the game: 800D1F86 000F. For the Japanese version, use 300D162E 000F. You will be able to play as Tofu and be able to use all weapons (even though they will be invisible). Tofu floats rather than actually walks, but you can hear footsteps when he moves.