Defeating Gabriel:-  Use your Dragon Breath gun to take away more life than any other gun you have.

Defeating the Vermin Demon Boss:-  At about the end of the second level, you will find the Sangre de Dio. After you solve the puzzle to unlock the dagger, pick it up and Constantine will start talking to himself. After about five seconds, an intermission sequence will start and the Vermin Demon will start to form. When the fight starts, do not waste your bullets. Pick up the screeching beetle that is on the left wall when you enter the room, if you do not already have one. This is the only weapon that has any effect on the Demon. Throw the beetle at the demon so that it falls to the ground and takes effect faster. This will paralyze it. Then, get close to it and melee it once with your weapon. It will disintegrate. If you hit it again, the Vermin Demon will hurt you. Step back, and now you can start shooting. The Witch's Curse gives a lot of damage. When it starts to integrate again, go to True Sight so that you can find and pick up the beetle again. Throw it again and repeat the process.

Defeating Kang-ore - At the center of Hell's Library you will meet Kang-ore. This dragon will rise up from the center of the room and breathe fire as well as dive towards you. If you run around the room shooting him in the head with either The Crucifier or The Witches Curse he will die rather quickly.

Defeating the Behemoth - This Boss hits the ground and causes you to fall. He also has the ability to draw you closer to him. If you have an Amityville Screeching Beetle throw it at him and it will stun him, then use your Dragon Breath Flame Thrower to hit the red swell in the middle of his chest. That is his only weak point. If you do not have the Dragon Breath Flame Thrower, you can use any of your projectile weapons to make short work of this Boss. Note: You will encounter this Boss again in Hell's Museum, but use this same method to defeat him again.