Ada Wong - Get a four star rating or higher in the Pueblo map.

Albert Wesker - Get a four star rating or higher in the Waterworld map.

Alternate controls - Disconnect the Nunchuck when the game loads. When prompted to attach the Nunchuck, attach the Classic Controller instead. You can play classic style Laser Sight and all.

Remove the Nunchuck, and insert a GameCube controller into port one. You will now have a laser sight on your weapons and be able to use all of the GameCube's normal controls.

Note: This is very helpful for sniping.

Alternate Title screen - Complete the main game once.
Ashley's knight armor - Beat Separate Ways once.
Ashley's pink outfit - Beat the main game once.
Assignment Ada - Beat the main game once.

Avoiding enemies at start - After you use the chief's false eye to open the door, walk up the hill until the truck comes at you. Shoot it and get back. Once it explodes, walk back up the hill, but go backwards. Keep going all the way to the castle and you will avoid facing the enemies that would normally appear.

Chicago Typewriter - Pass Assignment Ada once.

Defeating El Gigantes - When fighting an El Gigante in its second form, take out your Killer 7 and shoot the parasite, or climb on its back and cut it. Either way, this saves health, ammunition, and a lot of frustration.

Note: This is really only beneficial if you do not have one of the special weapons.

Defeating Krauser - When fighting Krauser, it is easier to fight him using your knife than shooting him. If you shoot him, he will usually block and counter. To avoid this, slash him three or four times. He will then either kneel or flinch. When he does this, take out your strongest weapon and shoot him. If you are low on bullets, you can use grenades and mines. If you are playing Separate Ways, it is easier to use your knife the entire time.

Defeating Milita - Instead of shooting for their head, shoot them in the knee, then walk up to them. Instead "Kick", "Suplex" will appear. This will usually kill them instantly. This will not work if their head is armored.

Defeating the Chainsaw Ganados - Use the following trick to defeat the Chainsaw Ganados on the mine cart easily. Make sure you have a Rocket Launcher and the Broken Butterfly Magnum from the castle. Also, have over six magnum rounds. When the first Chainsaw Ganado appears, shoot the Rocket Launcher at him before the other Ganados get in the way. For the second one, pump all your Magnum rounds into him. If that does not kill him, then use your Striker or Riot Gun. Note: You might get damaged during all of this; make sure that you have at least three First Aid Sprays, and two Herb Mixes (Green, Red, or Green, Red, Yellow) to use if your health gets too low.

Defeating the Regenerator - If you find your rifle is empty, you can also defeat the Regenerator by shooting a mine into the spot around the parasite. If it is on its back, shoot out its legs with your handgun, then fire a mine into its back. If this does not work, find out where the parasite is on the Regenerator and try again.

Defeating U3 (It) - While you are in the giant crates, you can maneuver around U3. When you get to the gate, it will follow you. Run around and shoot it, bringing it closer to the explosive barrels. When you run out of barrels, fire either your shotgun or magnum.

Ditman - Go to the inventory screen and select the Stricker. Exit from the inventory and press the B button and then quickly press the minus button. Equip any weapon besides the Stricker and leave the inventory screen. Now the glitch is activated and you can move twice as fast and shoot twice as fast but once you select the Stricker, the glitch will be deactivated.

Easily unlock characters in Mercenaries mode - When starting Mercenaries mode, play as Leon and go to the castle. It is much easier to get a good ranking because you can give the enemies a suplex, which almost always kills them in one hit. When you get Jack Krauser from the castle, you can then go to other areas, and it will make it much easier because of his arm.

Easy money - When you get to the church, shoot the bell. Every three times you shoot it, some villagers will appear. Kill them, and you will get anything from Pesetas to ammo and herbs. You can do this as many times as desired. This is effective if you have a lot of ammunition or the Chicago Typewriter.

To earn easy money while playing through the game again, carry an empty Handcannon. It costs no money to have, but you will pick up ammunition for it occasionally. This is worth more than any other type of ammo in the game. After collecting the ammunition, sell it to the merchant. Try using the Chicago Typewriter as your main gun while doing this.

HandCannon - Get a 5 star in all stages with all characters in the Mercenaries.

Hidden videos - There are two hidden cinematics accessible at the title screen. One can be accessed by remaining idle at the main menu until it starts. The other can be seen by pressing B on the Wii-mote at the main menu.

HUNK - Get a four star rating or higher in the Island map.

Infinite Rocket Launcher - Pass the game once.

Jack Krauser - Get a four star rating or higher in the Castle map.

Leon hat trick - To make Leon do a special trick with his hat, unlock the gangster costume and Chicago Typewriter. At any point in the game while in Leon's gangster costume, take out the Chicago Typewriter, aim, and shake the Wii-mote to reload. Leon will make a noise and move his hat. If you do this four times, he will throw his hat in the air and catch it on his head.

Leon S. Kennedy - Initially available.

Leon's R.P.D. uniform - Beat the main game once.

Leon's suit - Beat Separate Ways once.

Luis kills Leon - During the house scene shortly after getting Ashley, shoot Luis five or six times. There will be an intermission where Luis is shot in the arm. He will then say "Adios, Leon!" and shoot him twice in the heart.

Note: This will cause a game over.

Maltilda - Pass the game once.

Mercenaries - Beat the main game once.

Movie Browser - Beat the main game once.

Opening doors quicker - When the "Open" command appears by a door, tap A(2) to kick it open quickly. Doing this will also damage any enemies behind the door at the time you kick.

Plagas Removal Laser (PRL 412) - Beat the main game on Professional Mode.

Reticule feedback - Equip your handgun and aim the on-screen reticule at any torch or suspended light. Some times the reticule will turn red and deliver a slight jolt in the Wii-mote to indicate ammunition or a treasure that you can shoot from the light and retrieve. This is a slight advantage not available in previous versions of the game.

Saving ammunition - If you find yourself surrounded by some parasites of Los Ganados or los Illuminados and do not want to waste ammunition, quickly throw a flash grenade. Once it explodes, it should make the parasites explode, saving your other ammunition.

Separate Ways - Beat the main game once.

Spinel - When enter the bedroom after the garden, look on the roof of the bed. You should see a sparkling object. It is a spinel.

Wii Edition credits - Beat the main game once, then check the Bonus option in the Extras section of the main menu. You'll see an option for Wii Edition credits and can view the people responsible for porting Resident Evil 4 for the Wii.